PHARMACOTHERAPY

Volume 25 • Number 5 • 637 -- 777


ORIGINAL RESEARCH ARTICLES
637 -- Antithrombotic Effects of Rosiglitazone-Metformin versus Glimepiride-Metformin Combination Therapy in Patients with Type 2 Diabetes Mellitus and Metabolic Syndrome
Giuseppe Derosa, M.D., Ph.D., Antonio V. Gaddi, M.D., Ph.D., Mario N. Piccinni, M.D., Leonardina Ciccarelli, M.D., Sibilla Salvadeo, M.D., Emmanouil Peros, M.D., Morena Ghelfi, Ilaria Ferrari, and Arrigo F. G. Cicero, M.D.

646 -- Effects of Calcineurin Inhibitors on Sirolimus Pharmacokinetics During Staggered Administration in Renal Transplant Recipients
Fe-Lin Lin Wu, Ph.D., Meng-Kun Tsai, M.D., Ph.D., Russel Rhei-Long Chen, Ph.D., Shao-Wen Sun, Ph.D., Jin-Ding Huang, Ph.D., Rey-Heng Hu, M.D., Kuo-Hsin Chen, M.D., and Po-Huang Lee, M.D., Ph.D.

RESEARCH REPORTS
654 -- Electrocardiographic Effects of an Ephedra-Free, Multicomponent Weight-Loss Supplement in Healthy Volunteers
Bokyung Min, Pharm.D., Brian F. McBride, Pharm.D., Michael J. Kardas, B.S., Agron Ismali, B.S., Vinnita Sinha, Pharm.D., Jeffrey Kluger, M.D., and C. Michael White, Pharm.D.

660 -- Persistence, Switching, and Discontinuation Rates Among Patients Receiving Sertraline, Paroxetine, and Citalopram
C. Daniel Mullins, Ph.D., Fadia T. Shaya, Ph.D., M.P.H., Fanlun Meng, M.S., Junling Wang, M.S., and David Harrison, Ph.D.

668 -- Effect of Clinical Characteristics on Neutropenia-Related Inpatient Costs Among Newly Diagnosed Non-HodgkinÕs Lymphoma Cases During First-Course Chemotherapy
Elizabeth A. Chrischilles, Ph.D., Donald G. Klepser, M.B.A., John M. Brooks, Ph.D., Margaret D. Voelker, Ph.D., Shari S. Chen-Hardee, M.S., Shane D. Scott, Pharm.D., Brian K. Link, M.D., and David J. Delgado, Ph.D.

676 -- Development and Validation of a Diabetes Mellitus Severity Index: A Risk-Adjustment Tool for Predicting Health Care Resource Use and Costs
Vijay N. Joish, Ph.D., Daniel C. Malone, Ph.D., Christopher Wendel, M.S., JoLaine R. Draugalis, Ph.D., and M. Jane Mohler, Ph.D., M.P.H.

685 -- Reduction in Warfarin Adverse Events Requiring Patient Hospitalization After Implementation of a Pharmacist-Managed Anticoagulation Service
Christy Locke, Pharm.D., Susan L. Ravnan, Pharm.D., FCSHP, Rajul Patel, Pharm.D., and James A. Uchizono, Pharm.D., Ph.D.

BRIEF REPORT
690 -- Experience with Community-Based Amphotericin B Infusion Therapy
Preeti N. Malani, M.D., Daryl D. DePestel, Pharm.D., James Riddell, IV, M.D., Susan Bickley, Pharm.D., Lisa R. Klein, Pharm.D., and Carol A. Kauffman, M.D.

REVIEWS OF THERAPEUTICS
698 -- Use of Highly Active Antiretroviral Therapy in Patients with Renal Insufficiency
Joan M. Duggan, M.D., Eric G. Sahloff, Pharm.D., and Varsha V. Moudgal, M.D.

709 -- Cinacalcet: A New Treatment for Secondary Hyperparathyroidism in Patients Receiving Hemodialysis
Cecelia A. Byrnes, Pharm.D., and Brian M. Shepler, Pharm.D.

717 -- Gemifloxacin for the Treatment of Respiratory Tract Infections: In Vitro Susceptibility, Pharmacokinetics and Pharmacodynamics, Clinical Efficacy, and Safety
Sujata M. Bhavnani, Pharm.D., M.S., and David R. Andes, M.D.

MINIREVIEWS
741 -- Current Issues in the Development of a Vaccine to Prevent Human Immunodeficiency Virus Insights from the Society of Infectious Diseases Pharmacists
Eric G. Sahloff, Pharm.D.

748 -- High-Dose Methotrexate in Acute Lymphoblastic Leukemia: Where Is the Evidence for Its Continued Use?
Elpis Mantadakis, M.D., Peter D. Cole, M.D., and Barton A. Kamen, M.D., Ph.D.

CASE REPORTS
756 -- Dilated Cardiomyopathy and Acute Liver Injury Associated with Combined Use of Ephedra, g-Hydroxybutyrate, and Anabolic Steroids
Brychan M. Clark, M.D., and Richard S. Schofield, M.D.

762 -- Lone Atrial Fibrillation Associated with Creatine Monohydrate Supplementation
Ryan T. Kammer, Pharm.D.

765 -- Azacitidine-Induced Interstitial and Alveolar Fibrosis in a Patient with Myelodysplastic Syndrome
Christopher D. Adams, Pharm.D., Paul M. Szumita, Pharm.D., Steven A. Baroletti, Pharm.D., and Craig M. Lilly, M.D.

769 -- Enoxaparin-Associated Retroperitoneal Bleeding in Two Patients with Renal Insufficiency
Ahmed Malik, M.D., Richard Capling, D.O., and Bahar Bastani, M.D.

773 -- Celecoxib-Induced Nephrotoxicity in a Renal Transplant Recipient
Timothy M. Clifford, Pharm.D., Mehrnaz Pajoumand, Pharm.D., and Thomas D. Johnston, M.D., FACS